The oral and gastrointestinal tract microbiome constitute the bulk of the overall human microbial load. The interconnected network of microorganisms present unique opportunities for advancing human health therapy.
with the right dietary and oral hygiene habits
Indeed, the use of a lyophilized powder does not offer a protection to the bacteria, and therefore get damaged.
This is interesting to study for example digestibility of prebiotic substrates and its subsequent fermentability in the colon or the survival of pathogens or probiotics in the upper digestive tract before they reach the colon environment.
This approach has mainly been used to investigate the activity and stability of probiotics and prebiotics during gastrointestinal transfer, the microbial conversion of bioactive food components (e.g. phytoestrogens), the metabolism of pharmaceutical components, the efficacy of colonic targeted delivery systems and the conversion and biological (in)activation of food and/or ingested environmental contaminants.
Unique scientifically validated dynamic model.
160 peer-reviewed scientific publications.
SHIME® simulates both the upper and lower GT
SHIME® mimics the conditions in all colon regions
SHIME® covers the pH variety and complexity.
The gastric compartment works at a fixed pH of 2.0
The small intestine compartment typically operates at slightly acidic to neutral conditions
The pH of the colon compartments is controlled between
SHIME® brings the possibility of simulating the microbiome from different human target groups e.g
No. Our Lactobact® probiotics are shelf stable and don’t need refrigeration.
In the intestine live many small microorganisms and form the so-called intestinal flora . It consists of countless good bacteria. An antibiotic works against bacteria. Frequently, so-called broadband antibiotics are used. In other words, they are not specifically geared to a type of bacteria and destroy not only the bad bacteria but also the good intestinal bacteria. As a result, pathogenic germs in the gut can spread, such as clostridia . These cause strong diarrhea after taking antibiotics. Diarrhea during or after antibiotic therapy is also called antibiotic- associated diarrhea (AAD).
The Clostridia , which are located in the intestinal flora , ensure diarrhea when taking antibiotics. Depending on how fast these bacteria multiply, diarrhea associated with antibiotic therapy may occur after one to two days . In the worst case, diarrhea persists for up to 2 weeks after taking the antibiotic . In general, a gut flora can recover from the clostridia and return to normal equilibrium. This can take up to a year.
The more antibiotics and especially broad-spectrum antibiotics are taken, the greater the damage in the balanced intestinal flora . Harmful germs like Clostridia can spread more and more and this leads to diarrhea after taking antibiotics. If the intestinal flora can not recover, it can not only cause digestive problems. Vitamins and other nutrients can no longer be absorbed properly by the intestine. The immune system, which is 80% in the intestine, can get out of joint. Incompatibilities are the result. This often results in allergies, such as hay fever.
In order to rebuild the complex and diverse intestinal flora , one needs a probiotic agent containing several selected bacterial strains. In addition, it should be high doses, as antibiotics repeatedly kill bacteria in the gut. Therefore, the agent Lactobact® AAD is recommended for diarrhea caused by antibiotics . The remedy should be taken already during the therapy with the antibiotic, however, within a temporal distance of approx. 2 hours. After antibiotic therapy, the agent Lactobact® PREMIUM is recommended for the long-term development of a complex intestinal flora .
If no additional means of intestinal florasanation are taken, the intestine needs at least 6 weeks, but in many cases up to a year to fully recover. It depends on the individual and their lifestyle. With additional intake of Lactobact® AAD to the antibiotic and a subsequent 4 weeks cure with Lactobact® PREMIUM , the intestinal flora is then largely built up. The likelihood of diarrhea with antibiotics being taken with the medication is thus reduced by 90%.
Intestinal flora is the term for a multiplicity of bacteria which live in our intestine. They are on the mucus layer lining the intestine. The bacteria in the intestine bring a weight of about 1-2 kgs on the scales. Their tasks are vital to the body. For example, they are involved in enzyme and vitamin formation and in the breakdown of plant compounds that we otherwise would not digest. In addition, our intestinal flora communicates with the immune system and supports the formation of anti-inflammatory messengers. The protection against pathogens also comes from the intestinal flora.
A disturbed intestinal flora is called dysbiosis in medical parlance. This means that pathogenic bacteria in the intestine could multiply many times. This leads to an altered bacterial colonization. The consequences of a disturbed intestinal flora can not only be diarrhoea, constipation and flatulence, but also inflammatory diseases occur. If it comes to a dysbiosis, you can with a balanced, high-fiber diet, exercise and with probiotics preparations to rebuild the intestinal flora.
A disturbance of the intestinal flora can come about through various causes. An unbalanced diet high in fat, sugar, and low fiber negatively affects the intestinal flora composition. Also, the factor of movement plays a major role for a balanced healthy bacterial composition in the intestine. Antibiotics are a common problem. Antibiotics have to be taken for some diseases, but unfortunately they not only kill pathogenic bacteria but also kill our healthy intestinal bacteria. Babies often suffer from disturbed intestinal flora if they are born by caesarean section or are not breastfed.
“Probiotics are living microorganisms that, when consumed in adequate numbers, have a health effect on the host,” is the WHO / FAO definition of probiotic intestinal bacteria since 2001. This means that probiotic gut bacteria must meet specific requirements. First and foremost, it is important that the bacteria survive the gastric and bile acids without damage. Because unprotected strains of bacteria can lose their viability within a very short time and thus become ineffective. The products should also be present in high concentrations.
There are a variety of probiotic bacterial strains with clinical evidence in the gastrointestinal tract. In medical use, the following probiotic species are predominantly used: lactobacilli , bifidobacteria , Enterococcus faecium and Escherichia coli. A combination of selected probiotic intestinal bacteria in high concentration ensures the desired health effect.
There is now a wealth of clinical study material on the administration of probiotic intestinal bacteria . Probiotic intestinal bacteria are used at any age. In babies born as cesarean birth or not breastfed, it was found that the intestinal flora is different in composition compared to vaginal birth and nursing children. When occurring three-month colic also like probiotics are used. Older children are often affected by asthma, allergies and atopic dermatitis or antibiotics cause a shift in the intestinal flora . Meanwhile, diseases of the nervous system are increasingly in the focus of the researchers, in which a maloccupation of the intestinal flora seems to play a role